[nsp] NAT for not directly connected n/w??

[pakucable]

HI folks,

192.168.100.0/24                             s1    s2
    |                                                      |      |
PC/Router-10.10.1.1----10.10.1.2-s0 Router1
                                                                |eth0 10.10.100.2
                                                           Switch
                                                                |
                                                                |10.10.100.1
                                                         LinuxBox2
                                                                |(public IP)
                                                             Internet

Is it possible to NAT after routing ??
I want to do NAT for 192.168.100.0/24  on LinuxBox2. Practically is it possible ? or I can do NAT for directly connected n/w
only.

Thanks
paku